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Successively, the gut microbiota is highly sensitive to environmental signals, receiving, integrating and responding to the information not only from the different organs of the body, but also from external influences like diet, physical activity, psychological and physical stress, sleep restrictions, socioeconomic status, drugs, antibiotics, exposure to pets, noise, and temperature [63]

Impaired mitophagy and fragmented mitochondrial morphology are emerging as novel contributors to neuronal vulnerability in AD (Figure 3)

Human plasminogen is highly susceptible to peroxynitrite inactivation

(31) demonstrated through precision nutrition research that adjustments in dietary macronutrient proportions can induce significant changes in gut microbiota composition within days, providing a theoretical foundation for improving metabolic health through dietary intervention