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The fixed sections were stained with anti-IL-6 antibody (Abcam) and anti-CD31 antibody (Abcam)

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Reduced acinar cell replacement is likely due to decreased cell proliferation rather than cell death as we measured a reduction in Ccnd1 , while markers of cell death [activated caspase3 (CASP3 + ) cells in Fig EV3G or Bax, Pmaip1 (NOXA) and Bbc3 (PUMA) in Fig EV3H)] were either not observed or remained unchanged