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Potential synergistic supplementation of NAD + promoting compounds as a strategy for increasing healthspan

This leads to a faster breakdown of glutathione (GSH), a key antioxidant

Increased levels of miR-144 have been found in a subset of HbSS patients with typical severe anemia and reduced NRF2 protein levels, causing a reduction of GSH regeneration and impairing cell response to OS, thereby providing a possible mechanism for the increased anemia severity seen in these patients [221]

Individuals who are pregnant, nursing, taking medications, or managing a medical condition should consult their healthcare practitioner before using NAC