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Description

Blood was collected from MDD subjects and healthy age-matched controls

G.BlencoweN

A also stimulates the activation of NADPH oxidases (NOXs), integrin Iib-3, and ROS, promoting platelet adhesion, increasing levels of the endogenous inhibitors plasminogen activator inhibitor-1 and endothelin-1 (ET-1), and resulting in thrombosis, capillary constriction, and impaired blood flow [99, 181, 182]