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For example, studies have shown that glucose-6-phosphate dehydrogenase (G6PD) is a key regulatory enzyme in the HMP shunt, and its activity is regulated by factors such as NADP+ and oxidative stress

PGC-1 has been demonstrated to upregulate Nrf2 in order to control mitochondrial biogenesis (Wu et al., 1999

Overwhelming bursts of ROS, often supplemented by ROS-induced ROS release, also often differ from localised ROS-S in terms of physiological response [136]

Comparatively fewer studies have globally analyzed PTM distributions across organelles to reveal PTM-specific localizations and/or functions, though some studies have begun to shed light on this aspect of regulation (Zhou et al., 2010