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While full-length hGH activates growth hormone receptors causing multiple effects (growth promotion, insulin resistance, lipolysis), AOD9604 is studied for its receptor-independent actions on fat cells

ISSN 0083-6729

The Phase 3 protocols incorporated a more gradual titration scheme designed to improve tolerability and reduce early discontinuations, an approach consistent with the dose-escalation strategy used successfully for injectable GLP-1 agonists

In scientific literature, AOD9604 is recognized as a modified analog of the natural hGH fragment, featuring a disulfide bridge between cysteine residues (Cys182 and Cys189) that stabilizes its tertiary structure and enhances metabolic stability