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Additionally, another NADPH-generating enzyme IDH1 was found to be crucial for the anchorage-independent growth, a property shared by many malignant cells

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It would also be valuable to investigate tissue-specific or tumor subtype-specific expression patterns of ncRNAs, as well as their interactions with epigenetic modifiers, transcription factors, and signaling pathways such as PI3K/AKT or MAPK in the context of chemoresistance

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