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Toxicol ., 2 , 349355

Wnt canonical pathway activates macropinocytosis and lysosomal degradation of extracellular proteins

doi: 10.1038/nri2744 170 GuoFFCuiJW

This synthesis further demonstrates that anesthesia contributes to POCD through three established pathwaysmicroglia-mediated neuroinflammatory activation, disturbances in cerebral hemodynamics and metabolic homeostasis, and direct impairment of synaptic plasticity and neurogenesis