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For example, histamine released from cells lining the stomach activates H2 (histamine 2) receptors, which cause stomach acid to be produced

1068 Metformin also reduces insulin-like growth factor (IGF) signaling pathway activity, decreases glucose absorption, and promotes glucose breakdown, thus reducing energy supply and growth of cancer cells

Overall this study supports the notion that metabolic abnormalities in individuals with ASD may be amenable to targeted treatments and provide some insight into the mechanism of action of these treatments