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Mitochondrial dynamics, including fission and fusion, are integral to maintaining the malignant phenotype of tumors by regulating mitochondrial function, energy metabolism, tumor cell survival, resistance to apoptosis, invasion, metastasis, and responsiveness to chemotherapy and radiotherapy [38, 39]

In a placebo-controlled trial, Withania somnifera (Ashwagandha), administered at 600 mg/day for 8 weeks, significantly improved memory, executive function, and attention in patients with mild memory impairment, underscoring its potential in early intervention (Choudhary et al., 2017)

However, clinical translation faces significant challenges including off-target toxicity, limited efficacy, lack of predictive biomarkers, and emergence of adaptive resistance mechanisms

NO is synthesized by nitricoxide synthase (NOS) during the conversion of l-arginine to l-citrulline, while O 2 and other ROS are generated by the membrane-bound NADPH-dependent oxidases (NOX) [75]