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Astrocytic lactate dehydrogenase a regulates neuronal excitability and depressive-like behaviors through lactate homeostasis in mice

2018 doi: 10.3390/JCM7120490

It has been observed that the apoptotic process in paclitaxel induced-painful neuropathy is due to the permeability transition pore opening, with the consequent cytochrome c release and Ca 2+ homeostasis dysregulation (Areti et al., 2014)

The hallmarks of PD are motor deficits, the spreading of pathological -synuclein clusters in the central nervous system, and neuroinflammatory processes