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Eur J Neurosci 19(8):20692079 Renna M et al (2013) IGF-1 receptor antagonism inhibits autophagy

What peptides lengthen telomeres

Telomerase activation is its signature mechanism: Epitalon can activate telomerase and lengthen telomeres in human cells, extending their replicative lifespan beyond the Hayflick limit, while preserving youthful morphology and function, though this benefit must be weighed against potential cancer risks

(1998) characterized the compounds as Ang IV receptor agonists and some of them, e.g., 8 with the straight four-carbon chain of the Nle residue at position one, exhibited very high affinity to the binding site (IC50 values 30-fold higher affinity (Ki = 1.7 nM) than Ang IV and improved both selectivity and metabolic stability (Lukaszuk et al., 2008