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The latter can be caused by complete or partial deficiency of the enzyme methylmalonylCoA mutase, which requires vitamin B12 as a co-factor (5deoxy-adenosyl-cobalamin (AdoCbl)) (Figure 22b.7)

Hakmaoui et al., 2007)

A recent study found that the ferroptosis inducer erastin can induce cellular autophagy, and autophagy can trigger ferroptosis by degrading ferritin and transferrin receptor 1 (TfR1), resulting in the accumulation of intracellular iron

The findings of the present study demonstrate that a high-fat, high-sucrose diet, which causes chronic hepatosteatosis similar to human fatty liver, reduces hepatic NAD + levels and consequently diminishes mitochondrial content, function, and adenosine triphosphate production