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Impaired mitochondrial function in brain cells reduces plasticity, impairing synaptic functioning and decreasing cellular resilience.[ref] Is elevated cortisol the only way to cause mitochondrial dysfunction

SIRT1 deficiency interferes with membrane resealing after cell membrane injury

However they also show differences in the overall fold with the presence of a DsbA-like domain inserted within the N-terminal thioredoxin-like domain 6