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Description

SIRT2 has been previously identified as a key delactylase that removes the lactyl group from pyruvate kinase M2 (PKM2)-derived synthetic peptides (99)

Clayton RJ, Iber FL, Ruebner BH, Mckusick VA

Notably, our study provides the first demonstration that ChaC1-catalyzed GSH depletion potentiates AUR-induced lethality, distinct from prior reports of BSO-enhanced cytotoxicity in TXNRD1-deficient/inhibited systems [31, 32]

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