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venous blood vessels, and thereby does not tend to result in significant postural hypotension preferentially dilates arterioles Experimental studies indicate that its effect can be abolished by endothelial denudation, as well as pre-treatment with non-selective COX inhibitors or prostacyclin receptor antagonists, suggesting an endothelial-dependent mechanism involving COX-mediated formation of prostacyclin (Maille et al, 2016)

Unlike directly administering growth hormone, tesamorelin is a synthetic analogue of growth hormone-releasing factor (GRF), also known as growth hormone-releasing hormone (GHRH), allowing it to work with the body's natural hormonal pathways

They work with your existing biology to amplify or restore functions, not override the basics

doi: 10.1016/j.ajem.2020.11.003