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They demonstrated that melatonin (3 mg/kg, administered intravenously at 3, 6, and 12 h post-cecal ligation and puncture) significantly improved survival, stabilized blood pressure, restored vascular responsiveness to norepinephrine, and reduced organ injury markers

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51,53 The comprehensive impacts of these microbial metabolites suggest an immense therapeutic potential of a material that could harness the entirety of the gut microbiome's metabolic output

Biochem J 1987