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Acknowledgments The authors thank the staff of Beijing Anzhen Hospital of Capital Medical University and Beijing Institute of Heart, Lung and Blood Vessel Diseases

The acetyl group acts as a carrier molecule that facilitates transport across cellular membranes, allowing for more targeted delivery to neural tissue where tyrosine hydroxylase converts it into L-DOPA, the immediate precursor to dopamine synthesis

These drugs might combine a robust neuroprotective and anti-inflammatory effect with a potential pro-cognitive effect, and their development is supported by the association of GRM3 gene variants and motor and non-motor symptoms in PD patients