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Kosower et al [11] had previously reported that monobromobimane (a derivative of 1,5-diazobicyclo[3,3,0] actadiendiones) and non fluorescent compound with an electrophilic site, slowly reacted with glutathione to form fluorescent glutathione conjugate and that the reaction might be catalysed by glutathione transferase

Under oxidative stress, NRF2 was released from KEAP1, translocated into and accumulated in the nucleus to induce expression of its target genes, and increased the expression of antioxidant enzymes like SODs and HOs families 60

Cooke PS, Nanjappa MK, Ko C, Prins GS, Hess RA

at the site of ulcers, fistulas, or wounds