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Additionally, the high expense of these therapies and a variety of other disadvantages prevent the patients from benefiting from them (Jimmy & Jose, 2011)

(2018) 10:e8051

A similar reasoning can be used for autophagy modulation with lithium-based compounds, which was of no benefit in mouse models and had limited impact in human trials [88]

58,59 Magnesium may protect against hearing loss through several mechanisms, including its abilities to counteract excessive calcium concentrations, improve blood flow by promoting vasodilation, exert antioxidant effects, and help regulate excitatory neurotransmission