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The level of IGF-1 was higher in the serum during daytime and in the liver during night-time, but lower in the serum during night-time and in the liver during daytime ( BMAL1 deficient mice had altered circadian rhythm of circulating IGF-1 levels ( CRY1 and 2 deficient mice had reduced IGF-1 production ( Due to the difficulty in measuring pulsatile GH secretion, the interaction between the GH-IGF-1 axis and circadian clock warrants further detailed research

L-ARC and H-ARC groups were intraperitoneally injected with ARC 5 mg/kg/d and 10 mg/kg/d respectively on the basis of Vehicle, and SHAM and Vehicle groups were intraperitoneally injected with the same dose of normal saline

S12B, S12C)