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doi: 10.1021/acs.jmedchem.9b01238 105 HorningBDSuciuRMGhadiriDAUlanovskayaOAMatthewsMLLumKMet al

[4] These findings do not preclude a possible benefit among some individuals with low vitamin B12 levels, and more research is needed

One of the RCTs found significant mean improvements in Clinical Global Impressions-Improvement (CGI-I) score and cellular methylation capacity, but not in the Aberrant Behaviour Checklist (ABC), Social Responsiveness Scale (SRS) or GSH metabolism, with those who had the lowest methionine status at baseline (suggesting impaired methylation capacity) significantly more likely to respond to supplementation

doi:10.1007/s00404-022-06766-z