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Combined use with sequestrants (which bind metals) and other antioxidants (such as vitamin C) that work synergistically to preserve it is strongly recommended

Senescent but not young RBC, as obtained by density separation, are phagocytosed by macrophages, while phagocytosis of in vitro aged RBC requires opsonization with autologous IgG

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30 In vivo studies in lymphocytic choriomeningitis virus-infected mice have shown that mTORC2 prevents ferroptosis in virus-specific memory CD4 T cells by limiting lipid peroxidation and mitochondrial ROS accumulation, primarily through activation of AKT and inhibition of GSK3, thereby supporting their long-term survival