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This sustained activation amplifies cytokine production and exacerbates oxidative stress damage [15]

doi: 10.1111/jth.15313 144

Lipid peroxidation: control of cell proliferation, cell differentiation and cell death

Specific examples of methylation in detoxification: Arsenic detoxification requires sequential methylation: arsenite to monomethylarsonic acid to dimethylarsinic acid (the excretable form), catalyzed by arsenic methyltransferase (AS3MT) using SAM-e R Mercury undergoes methylation by gut bacteria, converting inorganic mercury to more toxic methylmercury (this is detrimental methylation, not detoxification) R COMT methylation of 4-hydroxy catechol estrogens prevents them from forming reactive quinones that generate ROS and DNA damage R 6