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Overall Conclusions Overall Conclusions GW-0742 is a promising candidate to enhance liver metabolism and reduce liver stress, act as an anti-inflammatory agent, normalize insulin sensitivity, and reduce neuronal stress

This well-known antioxidant effect has led during the past decade to an increased diffusion of GSH-based self-prescribed implementation by patients, aiming to prevent cell injury possibly leading to cancer onset or to reduce anticancer treatments toxicities when cancer has already been diagnosed

This pathway begins with glutaminase-catalyzed production of ammonium and glutamate, which drives arginine biosynthesis and is subsequently sensed by CASTOR1, leading to persistent mTORC1 activation