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They function by specifically binding and sequestering excess free copper ions, thereby cutting off the feed-forward cycle of oxidative stress and inflammatory amplification at its source

Moreover, in breast cancer, IGF-1 mainly upregulates cysteine-rich 61 (Cyr61) by activating the PI3K/AKT pathway and an increase in Cyr61 promotes the growth and invasion of breast cancer cells (27)

It is also important to note that most of these studies were conducted in specific geographical regions, and did not encompass all demographic groups

Pathophysiological mechanisms linking F-box only protein 7 (FBXO7) and Parkinsons disease (PD)