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Regarding the dose, differences were observed among acute and chronic supplementation protocols, although this review did not find significant improvements in moderate-intensity exercise performance parameters

aSyn overexpressing transgenic mice show elevated levels of S-nitrosylated Parkin and PINK1 and defects in mitochondrial quality control 79 , whereas aSyn-knockout cells and mice are resistant to the deleterious effects of RNS elicited by exposure to MPP+ or LPS 122