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Mutation can change the binding site of imatinib to the BCRABL (break point cluster regionAbelson murine leukaemia viral oncogene homolog 1) gene, thereby inhibiting the activity of imatinib amongst patients who have chronic myeloid leukaemia [87, 88]

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Gastrointestinal Associated IBS Pathophysiology Alteration in Gut Microbiota Under normal circumstances, mucus epithelium barrier confines microbes to the epithelial surface or intestinal lumen where homeostatic immune responses are induced to maintain barrier integrity and tolerance among commensal microbes

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