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Wolbachia is a maternally inherited, endosymbiotic bacterium found naturally in ~ 60% of the insect population (Hilgenboecker et al., 2008

However, due to the limited expression of ALT1/2 (or GPT1/2) and low transaminase activity, which restricts alanine biosynthesis, T cells need extracellular alanine for protein synthesis (135)

We note that the Ceribell EEG Headband and Ceribell Pocket EEG are not included on the Breakthrough Device designation and it therefore appears that only the software would be designated as the Breakthrough Device once market authorized, such that only the software would be eligible for new technology add-on payments under the alternative pathway

Crane et al., 2018)