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EBioMedicine 12 , 6871 (2016)

Moreover, their primary role is to reduce peroxides, protecting cells from oxidative damage and maintaining cellular integrity

While in most cases, the drug-induced kidney injury is reversible upon cease of treatment some medications could lead to chronic dysfunction such as papillary necrosis, tubulointerstitial nephritis, or prolonged proteinuria (Choudhury and Ahmed 2006)

KPV, a tripeptide fragment of -MSH, has been examined for its interaction with NF-B and MAPK-related inflammatory pathways, as well as for its transport via PepT1 under experimentally induced inflammatory conditions