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Furthermore, we also observe that some of the metabolic pathways are enriched with mostly essential activated enzymes (e.g., Lysine biosynthesis, Phenylalanine metabolism, Histidine metabolism, Pantothenate and CA biosynthesis, and Phenylalanine, tyrosine and tryptophan biosynthesis), whereas in some pathways none of the activated enzymes seems essential for growth (for example, Biotin metabolism, Lipoic acid metabolism, Taurine and hypotaurine metabolism, Various types of N-glycan biosynthesis, and Citrate cycle (TCA cycle))

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