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Reported side effects The side effects reported in trials and research protocols tend to be mild and transient: Common: Injection site reactions: redness, swelling, mild irritation at the injection location Headache: reported in some subjects, typically mild and temporary Mild gastrointestinal discomfort: occasional reports of nausea or upset stomach Less common: Temporary dizziness Slight increases in heart rate Minor liver enzyme elevations in some subjects These effects, when they occur, generally resolve without intervention and don't require discontinuation

doi: 10.1016/j.jconrel.2013.09.007 91 DesprsP

10.1093/infdis/160.6.1085 177

The characteristics of paediatric PFIC are summarized in Table 1