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Causes and Clinical Manifestations Hyperkalemia has many causes, including but not limited to, tissue injury, insulin deficiency, exercise, medications, and excess dietary potassium intake 8,9 : Trauma, massive hemolysis (destruction of red blood cells), and tumor lysis (rapid breakdown of cancer cells) may cause tissue injury, which in turn may cause hyperkalemia

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As discussed in the previous section, glutamine metabolism, which leads to ammonia accumulation, is active in a variety of immune cells