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Later, a phase III trial was conducted in Japan and demonstrated that PFD preserves VC, the primary outcome, and improves progression-free survival time, the second outcome in mild IPF patients (Taniguchi et al., 2010)

The activation degree of classical regulatory pathways such as PINK1/Parkin and BNIP3/NIX, as well as the patency of autophagic flux, directly determines the effect direction of mitophagy

Importantly, however, the clinical evidence that this broader mechanistic footprint translates into superior or additive outcomes over targeted agents in OA populations specifically remains limited and has not yet been tested in head-to-head clinical trials 30,31

You have to have faith that its working for you. Potential Side Effects and Precautions of NAD Supplements Some minor side effects that could be tied to NAD supplementation include: Headache Diarrhea Nausea Flushing Rashes Abdominal discomfort Digestive issues But again, the safety of NAD is pretty sound