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Microenvironmental influences on T cell immunity in cancer and inflammation

Inositol trisphosphate and diacylglycerol: two interacting second messengers

These immunogenic properties are particularly significant in glioblastoma, where ferroptosis-related gene signatures demonstrate strong predictive value for response to PD-1 blockade in recurrent tumors, suggesting an intrinsic synergy between ferroptosis and immune checkpoint inhibition [129]

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