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Samuel et al., 2018)

After ingestion, folate from food is hydrolyzed in the gut, where it is converted first to tetrahydrofolate by the enzyme dihydrofolate reductase and then to the active form 5-MTHF, by the enzyme MTHFR

Recent researches have indicated that OS is a significant factor in both the onset and progression of nutritional and endocrine diseases in children (Figure 4)