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What follows is theoretical framework based on individual compound dosing data and pharmacological principles

doi: 10.1038/nature14344 83 SongXLongD

MED1, a novel human methyl-CpG-binding endonuclease, interacts with DNA mismatch repair protein MLH1

The accumulation of unfolded proteins in the ER activates IRE1 through oligomerization and autophosphorylation, leading to the formation of signaling complexes with tumor necrosis factor receptor-associated factor 2 (TRAF2) and apoptosis signal-regulated kinase 1