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A comprehensive approach was adopted, utilizing international scientific databases like PubMed, Scopus, and specialized resources such as ClinicalTrials.gov to assimilate the latest research findings and clinical trial data

GLP-1 receptor agonist as a modulator of innate immunity

Considering its used off-label (that is, for reasons other than acne) to prevent aging, this is literally the opposite of what youd expect or hope to happen

Animal experiments have demonstrated that high-fat diet downregulates tight junction protein expression (such as occludin and ZO-1), reduces mucus layer thickness, and increases intestinal permeability (89)