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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 4), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification

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Proteins are long enough to fold into a stable, specific three-dimensional shape, and that shape is usually what does the work: an enzymes pocket or an antibodys binding site