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Although IFN- suppresses tumor-derived chemokines to inhibit the tumor trafficking of CXCR2 + CD68 + macrophages (associated with M2 polarization) by blocking the CXCL8-CXCR2 axis, thereby counteracting immunosuppression and overcoming therapeutic resistance, dysregulated IFN signaling can promote M2-skewed macrophage polarization, which compromises the efficacy of anti-PD-1/PD-L1 therapies [299]

10.1128/AAC.42.7.1587 216 WangG.LiX.WangZ

Initially, the animals received a single intraperitoneal injection of one of the following treatments: vehicle control (0.9% normal saline or 10% DMSO), cetirizine (10 mg/kg), Icatibant (1 mg/kg), celecoxib (50 mg/kg B

Parameters compared included age at symptom onset, gender, clinical symptoms, risk factors, autoantibodies, and cerebrospinal fluid findings