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The cystine-glutamate antiporter system X c imports the extracellular cystine into the cytoplasm while it exports intracellular glutamate into the extracellular space

Autophagosomes arise from a single membrane structure known as the phagophore, which elongates and then closes in on itself, sequestering cytoplasmic material in the process

Side-effects range from mild (nausea, injection-site discomfort) to serious and even life-threatening (allergic reactions, liver injury, systemic inflammatory response, endotoxin-related events)

Interestingly, a diet rich in MUFA was found to inhibit pirfenidone-induced adverse reactions and enhance its efficacy in the treatment of IPF [164]