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Other experiments were conducted using fresh samples

In acute rat diabetic models, streptozotocin-induced reductions in renal cortical protein degradation were observed, along with increases in the quantity of KFERQ-containing proteins

Sci Rep 2016

Metabolic re-wiring that limits the malate-aspartate shuttle and mitochondrial substrate oxidation, and promotes aerobic glycolysis, the re-oxidation of NADH by MDH1, folate cycle NADPH production, and pentose phosphate supply by the non-oxidative PPP may thus constitute a successful strategy for minimizing ROS production and supporting high proliferation rates in oxygen-rich environments