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In a recent study, intraperitoneal injection of liproxstatin-1 (Lip-1, a ferroptosis inhibitor) in rats reduced iron content and lipid peroxidation in spinal cord tissue, alleviating CCI-induced mechanical and thermal nociceptive abnormalities ( Table 1 ) ( Figure 5 In clinical treatment, the most ordinary drug used to treat MS is glucocorticoids (GC) (123)

The MDA concentration has been frequently used as an index of lipid peroxidation, which indicates oxidative injury of the cell plasma membrane (Tsikas, 2017)

Tissue sections were counterstained with DAPI (blue) and wheat germ agglutinin (WGA

By targeting two distinct receptor pathways simultaneously, physicians can utilize lower cumulative dosages of each peptide