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The SURMOUNT-4 study showed that participants who discontinued tirzepatide after achieving significant weight loss regained approximately two-thirds of the lost weight within a year

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Beyond month 6, the protocol moves into a maintenance phase

Although both 5-Aza and DAC have significantly improved the management of hematological tumors, these first-generation hypomethylating agents are rapidly hydrolyzed in aqueous acidic or basic conditions, resulting in poor bioavailability and limited half-life