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To clarify the causal relationships and stagedependent roles of these factors, we propose a conceptual framework for AD progression (1):Early AD (causal events): Disruption of cerebral iron homeostasis leads to regional iron accumulation, which primes neurons for ferroptosis through elevated ROS and impaired antioxidant defenses (2).Transitional AD (facilitative events): Ferroptotic stress promotes A aggregation and tau hyperphosphorylation

First, 132 mg PVP and 40 mg FeCl 3 6H 2 O were dissolved in 10 mL and 2 mL methanol, respectively

In general, nootropics are cognitive enhancers initially developed to address cognitive impairments

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