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Sustained release modalities are in clinical trials to help address this well-known problem

Normal haematopoietic stem cells (HSCs) are characteristically quiescent and adapt their metabolic profiles at a low demand status to maintain their survival and produce multipotent progenitors in the bone marrow (BM) niche (7, 8)

Mol Plant 2:344356 Queval G, Jaillard D, Zechmann B, Noctor G (2011) Increased intracellular H 2 O 2 availability preferentially drives glutathione accumulation in chloroplasts and vacuoles