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(Biochem Pharmacol 2018) documented a reduction of -35% in white adipose tissue, -40% in adipocyte volume, -5.1% in body weight and -30% in plasma cholesterol in just 11 days in obese mice (DIO), without any change in food intake

In aesthetic practice, it is often incorporated into mesotherapy protocols and skin-support programs, where vitamin-based injectable solutions are used to complement broader treatment strategies focused on skin quality and metabolic support

Some clients benefit from weekly injections, while others may need them monthly for maintenance

Diagnosis typically includes testing for anti-intrinsic factor antibodies (and sometimes anti-parietal cell antibodies)