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TPO-RAs activate the thrombopoietin receptor on megakaryocytes

Answer: Cagrilintide engages the amylin pathway on several fronts: it activates satiety centers in the brainstem, slows gastric emptying so meals satisfy longer, helps stabilize post-meal blood sugar, and appears to reduce reward-driven cravings for highly palatable foods

In-focus single-cell images were acquired with a 60 magnification and a low-speed flow rate using the INSPIRE software (EMD Millipore)

The animals were acclimatised to laboratory conditions (23 C, 12 h/12 h light/dark, 50% humidity, ad libitum access to food and water) for 2 wk prior to experimentation