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The suppression of the unspecific collagenase activity appeared after treatments with plant extracts of Cassia fistula [237], Curcuma heyneana [246], Eugenia dysenterica [220], Hibiscus sabdariffa [247], Litchi chinens [232], Magnolia officinalis [223], Malaxis acuminate [224], Manilkara zapota [225], Nephelium lappaceum [222], Passiflora tarminiana [240], Phyllanthus emblica [226], Piper cambodianum [228], Sclerocarya birrea [226], Sylibum marianum [225], and Tamarindus indica [222]

In models of pre-existing oxidative stress or injury, CGAs potent antioxidant properties are therapeutic (Figure 9)

In vitro studies have demonstrated that the iron overload induced by ferric ammonium citrate triggers ferroptosis in NPCs and increases MMP expression, accelerating ECM breakdown (5,33)

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