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doi: 10.1371/journal.pone.0005650 32 SnellingSJForsterAMukherjeeSPriceAJPoulsenRC

Astrocytes, positioned at the interface between the brain parenchyma and the perivascular space, which includes capillaries, larger arteries, and veins [66], play a role in the removal of A from the brain via mechanisms that include enzymatic degradation of A and the upregulation of efflux transporters for A at the BBB [67]